The plant sources leaf extract are shown to be very effective against extracoccus faecals. It’s a major microbe recovered from root canal.
Proline-riche Bacterinine against Gram-ves
They can enter bacteria cells without damaging the membrane. It uses Sbm-A, a bacteria proton which permits to create a drive transporter into cells.
This polypeptide contains several combinaisons of amino acids, one of them contains:
– Ten residues Proline
– Two arginine residues
This polypeptide is the best combinaison (1).
PAF-26 is a de NOVO designed hexapeptide antifungial.
It contains two motifs N-terminal with cationic region and a C-reminal hydrophobic region.
It’s a dynamic antifungial mode of affection involving electrostatic interactions with the cells of the membrane . The internalisation is possible and it kills the cell. The mode of killing is not clear nowadays.
Current researches on PAF-26 are made like:
- Analyzed by live cell imaging
- Attached a fluorescent tag
(1) Sadler & al. Biochemistry, 2002,41, 48