Mecanism about the action of antimicrobial peptides
Until today, the exact mechanism in despite of many recherches is still unknown.
We know the interactions between peptides and lipids which lead to membrane permeation.
Mechanism of action
Carpet model-lysine interacts with anionic phospholipids head groups.
The hydrophobic region interacts with the lipid bilayer disrupting bacterial membrane.
Hydrophobicity of the core residues determines ability of peptide to insert onto the membrane.